Julian McMahon as Jesse “Jess” LaCroix, FBI Supervisory Special Agent and Team Leader.
Kellan Lutz as Kenny Crosby, FBI Special Agent and ex-Army Intelligence officer.
Roxy Sternberg as Sheryll Barnes, FBI Special Agent and second in command of the Fugitive Task Force.
Keisha Castle-Hughes as Hana Gibson, FBI Special Agent and Intelligence Analyst for the Team.
Nathaniel Arcand as Clinton Skye, FBI Special Agent and LaCroix’s brother-in-law.
YaYa Gosselin as Tali LaCroix, daughter of Jess LaCroix and his wife, Angelyne and niece of Clinton Skye.
Miguel Gomez as Ivan Ortiz , an FBI agent originally from Los Angeles and who worked with the FBI's counter-terrorism unit in Washington D.C.
Alexa Davalos as Kristin Gaines, FBI Special Agent formerly with the Miami Field Office.
Dylan McDermott as Remy Scott, FBI Supervisory Special Agent and Jess's replacement as Team Leader.
Edwin Hodge as Ray Cannon, FBI Special Agent and former NOPD cop who later became a junior detective as well as the newest member of the Fugitive Task Force.